Effects of Iloprost on Oxygenation During One-lung Ventilation in Supine-positioned Patients
Status:
Not yet recruiting
Trial end date:
2023-06-01
Target enrollment:
Participant gender:
Summary
One-lung ventilation (OLV) is essential during mediastinal mass excision. However, OLV
induces a drastic increase of intrapulmonary shunt due to maintained pulmonary perfusion
through the nonventilated lung. In addition, it is reported that supine positioning of
patient during OLV, which is required during mediastinal mass excision, results in worse
oxygenation than lateral decubitus positioning.
Iloprost is a prostaglandin analogue and when inhaled during OLV, it acts selectively on the
pulmonary vasculature, reducing pulmonary vascular resistance of well-ventilated lung and
thereby alleviating ventilation-perfusion mismatch. The purpose of this study is to evaluate
the effects of inhaled iloprost on oxygenation during one-lung ventilation in patients
undergoing mediastinal mass excision.