Effects of IL-1 Beta on the HPA-axis in Obese Persons
Status:
Completed
Trial end date:
2016-07-01
Target enrollment:
Participant gender:
Summary
In obese individuals cortisol production and secretion is increased but the underlying
mechanism is not known. Obesity leads to a pathological activation of the innate immune
system partly driven by tissue production of IL-1β. Furthermore, IL-1β is also known to
stimulate the release of adrenocorticotropin hormone (ACTH). Therefore, the investigators
hypothesise that in obese individuals tissue inflammation stimulates ACTH via IL-1β, thereby
explaining the observed hypercortisolism.