Effects of Hydroxychloroquine on Oral Complaints of Sjögren Patients
Status:
Completed
Trial end date:
2009-01-01
Target enrollment:
Participant gender:
Summary
Chronic inflammation that comprises the exocrine glands' function leads to xerophthalmia and
xerostomia in Sjögren's syndrome. The oral consequences range widely and they are related to
decreased salivary output. Hydroxychloroquine may inhibit cholinesterase activity in salivary
glands via interference with antigen processing mechanism, and thus, the investigators'
hypothesis was that salivary gland function may be improved if treated with
hydroxychloroquine. The effects of hydroxychloroquine on the salivary flow rate, subjective
and objective parameters of the patients were also assessed.