Effects of Hormone Replacement Therapy on Arthralgia in Postmenopausal Women

• Status: Unknown status
• Trial end date: 2020-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

Arthralgia has been a common complaint in postmenopausal period which seems to be involved with estrogen depletion, although, its pathophysiology isn´t completely clarified. It seems to relate with the level of physical activity, climacteric symptoms and pain catastrophizing. In view of the multiple dimensions involved in arthralgia in postmenopausal women which characterize it as a complex phenomenon, this study aims to describe the effects of hormone replacement therapy in women aged between 45 and 55 years, considering estrogen as a possible anti-nociceptive factor.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hospital de Clinicas de Porto Alegre
• Treatments: Estrogens; Estrogens, Conjugated (USP); Hormones

Criteria

Inclusion Criteria:

• age between 45 and 55 years

• chronic arthralgia related to climacteric

• regular mammography and pap smear test in the last twelve months

• availability to attend hormone replacement therapy

• maximum of ten years of amenorrhea according to the criteria of Stages of Reproductive Aging Workshop (STRAW)

• without use of hormone replacement therapy, at least, previous six months

• no contraindication to hormone replacement therapy (current or past of breast and / or cervical cancer, severe current or recent heart disease, thromboembolism, hypertension with no control, metabolic diseases (but stable thyroid disease) and endometrial hyperplasia to be enlightened

• Informed consent

Exclusion Criteria:

• autoimmune diseases

• visceral pain (chronic pelvic pain, dyspareunia, irritable bowel syndrome)

• systemic diseases (rheumatic, neurological, oncology, sexually transmitted infection)

• body mass index of 30 or greater

• soy diet

• abuse of alcohol and drugs

• large surgeries