Effects of Hemofiltration and Mannitol Treatment on Cardiopulmonary-Bypass Induced Immunosuppression

• Status: Unknown status
• Trial end date: 2004-11-01
• Target enrollment: 0
• Participant gender: Male

Summary

After cardiac surgery with cardiopulmonar bypass, the LPS-stimulated cytokine response has been previously shown to be depressed. Therefore, in this trial the hypothesis was tested, whether simple immunomodulting interventions like the i.v. adminstration of mannitol of hemofiltration during cardipulmonary bypass can attenuate this immunosuppressing effect.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Saarland
• Collaborator: Else Kröner Fresenius Foundation
• Treatments: Mannitol

Criteria

Inclusion Criteria:

• male patients

• aged 35-80

• elective CABG surgery

Exclusion Criteria:

• previous cardiac surgery

• ejection fraction < 40%

• valvular heart disease

• myocardial infarction during the last 3 months

• evidence of concomitant malignant or immunologic diseases

• antecedent medication with corticosteroids or methylxanthines

• hemoglobin < 12 g/dl

• body mass index > 30