Effects of Glucagon Like Peptide 1 (GLP-1) Analogues on Fluid Intake

• Status: Completed
• Trial end date: 2017-05-12
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to elucidate whether GLP-1 analogues influence not only appetite but also thirst perception. It is hypothesized that GLP-1 analogues reduce fluid intake in healthy volunteers compared to Placebo.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Basel, Switzerland
• Treatments: Dulaglutide; Glucagon-Like Peptide 1; Immunoglobulin Fc Fragments

Criteria

Inclusion Criteria:

• Age 18 to 65 years

Exclusion Criteria:

• Known or probable central or nephrogenic Diabetes insipidus, based on patient's history

• Polyuria secondary to diabetes mellitus, hypokalemia, hypercalcemia

• Primary Polydipsia, defined as more than 4 liters fluid intake per day

• BMI <18 or >30kg/m2

• Pregnancy

• Previous treatment with GLP-1 agonists within the last 3 month

• History of pancreatitis

• Severe renal insufficiency (eGFR (CKD EPI) <30 ml/min/1,73 m2)

• Cancer