Effects of GLP-1RA on Body Weight, Metabolism and Fat Distribution in Overweight/Obese Patients With Type 2 Diabetes Mellitus

• Status: Recruiting
• Trial end date: 2025-02-23
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to analyze the effects of GLP-1RA on blood glucose, body weight, glucose and lipid metabolism and fat distribution in overweight/obese patients with type 2 diabetes mellitus.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: RenJi Hospital
• Treatments: Liraglutide; Metformin

Criteria

Inclusion Criteria:

• 1. Aged 18-65 years old; 2.BMI≥24kg/㎡, or waist circumference: > 85cm (for male) or > 80cm (for female); 3. Has been diagnosed with type 2 diabetes mellitus; 4. Good blood glucose control in recent three months: random blood sugar < 14mmol/L and HbA1c 6-9%;

5. Not received any drugs affecting glucose and lipid metabolism or weight loss surgery in the past one month.

Exclusion Criteria:

• 1. Abnormal weight gain caused by other endocrine diseases; 2. Severe metabolic diseases, such as diabetic ketoacidosis, hypertonic hyperglycemia; 3.Type 1 diabetes or other special types of diabetes; 4.Used drugs affecting glycolipid metabolism in the past three months; 5. Severe bleeding tendency that unable to complete venous blood collection; 6. Patients with MRI contraindications; 7. Severe renal insufficiency or severe liver insufficiency; 8. Patients with advanced malignant tumors; 9. Serious cardiovascular and cerebrovascular diseases; 10. Rheumatic and immune diseases; 11. Pregnant and lactating women.