Effects of GLP-1 Analogues on Fluid Intake in Patients With Primary Polydipsia (The GOLD-Study)
Status:
Completed
Trial end date:
2019-10-07
Target enrollment:
Participant gender:
Summary
Glucagon like Peptide -1 (GLP-1) receptor agonists are well known to stimulate
glucose-induced insulin secretion and to reduce energy intake. Recent findings from animal
and human studies suggest a role of GLP-1 in regulating water and salt homeostasis. GLP-1 has
been shown to reduce fluid intake after an oral salt load or during a meal - pointing to a
hypodipsic effect. The aim of this study is to elucidate whether these putative hypodipsic
properties of GLP-1 might be of advantage in persons with an exaggerated thirst perception as
is the case in patients with primary polydipsia.