Effects of Folic Acid Supplementation on Arsenic Lowering

• Status: Unknown status
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether folic acid supplementation are effective on arsenic lowering in a chronic, low-level arsenic exposed population.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wenzhou Medical University
• Treatments: Folic Acid; Vitamin B Complex

Criteria

Inclusion Criteria:

• Men or women more than 18 years of age and chronically exposed to arsenic (arsenic concentration of the drinking water >10ug/L);

• Population who had no folic acid supplementation in the 2 weeks before the study;

• Women of childbearing age agreed to use a reliable contraception method during the study;

• Everyone volunteered to participate and signed informed consent.

Exclusion Criteria:

• Pregnant or breast-feeding women;

• Allergic to folic acid;

• Having clearly defined allergic history;

• Reported long-term use of folic acid and other vitamins B;

• Having obvious signs or laboratory abnormalities which could affect the efficacy of folic acid;

• Unsuitable to participate in the study based on the judgment of the investigators;

• Not agree to cancel the medications which may affect serum folate concentration during the study period;

• Subjects who plan to become pregnant during the study or move out of the area within the study period;