Effects of Flutamide on Insulin and Glucose Metabolism in Women With Polycystic Ovary Syndrome
Status:
Terminated
Trial end date:
2012-02-01
Target enrollment:
Participant gender:
Summary
Polycystic Ovary Syndrome (PCOS) is the major cause of infertility in the United States. Many
women with PCOS demonstrate insulin resistance and a compensatory hyperinsulinemia.This is
due to both an intrinsic form of insulin resistance unique to PCOS and, in many cases,
acquired insulin resistance due to obesity. The importance of this observation lies in the
fact that hyperinsulinemia appears to play an important pathogenetic role in the
hyperandrogenism and anovulation of both obese and lean women with PCOS.
Phase:
N/A
Details
Lead Sponsor:
Virginia Commonwealth University
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)