Effects of Fludrocortisone on Norepinephrine-mean Arterial Pressure Dose-response in Septic Shock
Status:
Withdrawn
Trial end date:
2014-02-01
Target enrollment:
Participant gender:
Summary
Septic shock (associated with relative adrenal insufficiency) is characterized by decreased
arterial responsiveness to catecholamines. The association of hydrocortisone and
fludrocortisone has demonstrated an improvement in survival in septic shock patients. If
hydrocortisone has shown to increase vascular responsiveness, the role of fludrocortisone
remains to be elucidated. The purpose of our study is to investigate the effect of a
physiological dose of fludrocortisone alone on norepinephrine-mean arterial pressure
dose-response relationship, gastric mucosal perfusion and arterial stiffness in patients with
septic shock.