Effects of Fludrocortisone and Hydrocortisone in Healthy Volunteers With Aldosterone Induced Suppression
Status:
Terminated
Trial end date:
2009-03-01
Target enrollment:
Participant gender:
Summary
Septic shock (associated with relative adrenal insufficiency) is characterized by decreased
arterial responsiveness to catecholamines. The association of hydrocortisone and
fludrocortisone has demonstrated an improvement in survival in septic shock patients. If
hydrocortisone has shown to increase vascular responsiveness, the role of fludrocortisone
remains to be elucidated. The purpose of our study is to investigate the effect of a
physiological dose of fludrocortisone and/or hydrocortisone on phenylephrine-mean arterial
pressure dose-response relationship in healthy volunteers with aldosterone suppression
induced by intravenous sodium loading.