Effects of Flibanserin on the Pre- and Post-menopausal Female Brain
Status:
Active, not recruiting
Trial end date:
2021-12-21
Target enrollment:
Participant gender:
Summary
The purpose of the present study is to understand the neurobiological mechanisms of action
underlying sexual desire building on prior work Dr. Stephanie Cacioppo has done in which
desire was not manipulated. In the present project, Dr. Stephanie Cacioppo is manipulating
desire through Flibanserin (Addyi) vs. placebo and she will be measuring subjective sexual
desire as a manipulation check. The investigators will address this goal using a double-blind
randomized outpatient design and determine the pre-post neurobehavioral change in the
Flibanserin group and investigate the extent to which Flibanserin normalizes brain activity
in premenopausal women with HSDD and the extent to which regional brain activation is
associated with changes in symptoms and behavior (as measured with self-report measures of
sexual desire and/or eye-tracking movements).