Effects of Exercise Training and AGE-crosslink Breaker on Cardiovascular Structure and Function
Status:
Completed
Trial end date:
2011-06-01
Target enrollment:
Participant gender:
Summary
Healthy but sedentary aging leads to increased morbidity and mortality of cardiovascular
disease. This is partly due to the accumulation of Advanced Glycation Endproducts (AGEs) and
the stiffening of the myocardium and arteries. New medication has been developed to break
these AGE-crosslinks to improve cardiovascular compliance. The positive influence of regular
physical activity is well known for cardiovascular disease and aging. Therefore, what is the
most effective intervention, physical exercise and/or new medication AGE-crosslink breakers,
in improving the cardiovascular and cerebrovascular compliance and improving the endothelial
function in healthy sedentary elderly.