Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children
Status:
Unknown status
Trial end date:
2014-08-01
Target enrollment:
Participant gender:
Summary
Etomidate is an unique drug used for induction of general anesthesia and sedation. Adrenal
cortical inhibition by etomidate has received much attention. However wether the circadian
rhythm and pulse secretion pattern of cortisol in children are the same as that in adults is
not known. Moreover, the effect of etomidate on circadian rhythm changes and clinical
outcomes has never been carefully studied in children undergoing surgery. Our hypothesis is
that etomidate can relieve the changes of circadian rhythm of salivary cortisol in children
for 24-48 hours，and this does not make clinical outcomes worse postoperatively.