Effects of Escitalopram on the Sleep EEG Power in Patients With Major Depressive Disorder
Status:
Completed
Trial end date:
2018-12-30
Target enrollment:
Participant gender:
Summary
The main objective was to compare the differences of PSG parameters and plasma melatonin
levels before and after treatment with escitalopram for 8 weeks. Polysomnography (PSG) was
detected over a night and blood samples were collected at 4 h intervals for 24 h from 13 male
healthy controls and 13 male MDD patients before and after treatment with escitalopram for 8
weeks. The outcome measures included the levels of plasma melatonin, PSG parameters (include
sleep architecture and power analysis) and scales.