Overview

Effects of Epidural Anesthesia and Analgesia on the Prognosis in Patients Undergoing Pancreatic Cancer Surgery

Status:
Recruiting
Trial end date:
2021-12-18
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this randomized controlled trial is to investigate the effects of epidural anesthesia and analgesia on the overall survival，disease-free survival and recovery in patients undergoing pancreatic cancer surgery. This study will also evaluate the effects of this technique on neuroendocrine, stress and inflammatory response in these patients.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Fudan University
Collaborator:
Washington University School of Medicine
Treatments:
Anesthetics
Criteria
Inclusion Criteria:

1. Undergoing elective pancreaticoduodenectomy for pancreatic cancer .

2. ASA statusⅠ-Ⅲ.

3. 18 years to 80 years （adults）.

4. Able to understand, communicate and sign an informed consent form.

Exclusion Criteria:

1. Laparoscopic surgery.

2. Preoperative chemotherapy or radiotherapy.

3. Pregnancy.

4. Allergic to any drugs used during the study.

5. Long-term receiving β-blockers.

6. Complicated with chronic inflammatory diseases, autoimmune diseases, or long-term
receiving glucocorticoids or other immunosuppressants before surgery.

7. Abnormal coagulation functions (platelet count prior to surgery <100000/ μL , APTT
value is more than the normal value, INR > 1.3 or clopidogrel that cannot be
discontinued 7 days prior to surgery).

8. Complicated with severe heart disease (NYHA classification >3), severe renal
insufficiency (serum creatinine >1.8mg/dL or receiving renal replacement therapy),
severe hepatic disease (Child-Pugh classification

= C), diabetes (fasting blood glucose not in the range of 3.9-13.8 mmol/L ), or acute
infectious diseases (WBC>10000/μL) before surgery.

9. BMI > 35.

10. All contraindications to epidural anesthesia and analgesia.

11. Chronic opiate medication/drug abuse.

12. Complicated with severe mental illness, cognitive disorder or unable to collaborate
during the study.

13. Refuse to sign an informed consent form.