Effects of Duloxetine on Pain Relief After Total Knee Arthroplasty in Central Sensitization Patient
Status:
Unknown status
Trial end date:
2016-11-01
Target enrollment:
Participant gender:
Summary
This study aims to compare the effectiveness of duloxetine after total knee arthroplasty in
Central sensitization patient. Central sensitization plays an important role in the chronic
pain experienced by osteoarthritis patients.Elimination of the nociceptive input from the
damaged joint by total joint arthroplasty was not always followed by a complete resolution of
symptoms. Patients with high levels of preoperative pain and low pain thresholds had a higher
risk of persistent pain after total knee arthroplasty (TKA), which has been interpreted as
evidence of central sensitization. Thus, the presence of central sensitization before surgery
in Osteoarthritis patients may be an important contributing factor to postoperative pain
versus adequate analgesia. Preclinical models of central sensitization suggest that
duloxetine is effective in the treatment of persistent pain. Investigators will compare the
pain following TKA of central sensitization patients in duloxetine group (n=50) with those in
non-duloxetine group (n=84). Investigators will classify the central sensitization patients
by central sensitization inventory and divide the central sensitization patients in to 2
groups (duloxetine and non-duloxetine group) randomly. Investigators checks the visual
assessment scale at preoperative, postoperative 1, 2,6,12 weeks. All participants will
receive postoperative pain control after TKA using the same pain control regimen except
duloxetine.