Effects of Dual Bronchodilator Treatment on Cardiopulmonary Interactions in COPD
Status:
Completed
Trial end date:
2018-06-30
Target enrollment:
Participant gender:
Summary
The deleterious consequences of lung hyperinflation seem not to be restricted to the
respiratory system in patients with chronic obstructive pulmonary disease (COPD). Cardiac
function, in particular, is strongly influenced by changes in lung volumes and intra-thoracic
pressures. In this context, strategies to reduce lung hyperinflation and the work of
breathing can positively impact upon cardiac output and blood flow redistribution to
peripheral muscles in these patients. There is growing evidence that combination of
bronchodilators of different classes is an efficacious and safe strategy for further
improving airflow obstruction and hyperinflation in patients with more advanced COPD.
Therefore, we aim to investigate that, compared with placebo, a novel LABA/LAMA fixed
combination (tiotropium 5 mcg plus olodaterol 5 mcg via Respimat® (Inspiolto®) (TIO/OLO)
would decrease lung volumes at rest and during exercise, thereby improving: 1) central and
peripheral hemodynamics and 2) arterial oxygenation, with positive consequences on skeletal
muscle oxygenation and exercise tolerance in hyperinflated patients with moderate to very
severe COPD.