Effects of Doxycycline on Persistent Symptoms Post-neuroborreliosis

• Status: Completed
• Trial end date: 2008-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this randomised, double-blind crossover study was to determine whether Doxycycline has an impact on the persistent symptoms post-neuroborreliosis, through alterations in the immune response and whether such an effect could influence the clinical outcome.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Linkoeping University
• Treatments: Doxycycline; Tetracycline

Criteria

Inclusion Criteria:

• a history of adequately diagnosed and treated neuroborreliosis (presence of intrathecal borrelia-antibody production)

• persistence of symptoms (with debut in conjunction with neuroborreliosis) of typical character, such as headache, radiculitis, cognitive dysfunction, fatigue, mood disorders, paresthesia or paresis > 6 months post-treatment of neuroborreliosis

Exclusion Criteria:

• systemic immunosuppression (treatment with corticosteroids, cytostatics etc)

• ongoing infection at inclusion

• allergy against doxycycline

• pregnancy

• breast feeding

• psychiatric disease

• multiple sclerosis

• rheumatoid arthritis

• diabetes mellitus type 1 or II

• inflammatory systemic diseases

• liver ohc kidney dysfunction

• treatment with didanosine, quinapril, antacids

• malignancy