Effects of Different Doses of Dexmedetomidine on Postoperative Cognitive Dysfunction in Elderly Hypertensive Patients

• Status: Unknown status
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to identify the effects of different doses of dexmedetomidine on postoperative cognitive dysfunction in elderly hypertensive patients

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: First Affiliated Hospital Xi'an Jiaotong University
• Treatments: Atracurium; Cisatracurium; Dexmedetomidine; Etomidate; Fentanyl; Midazolam; Propofol; Remifentanil; Sevoflurane

Criteria

Inclusion Criteria:

• Written informed consent

• Elective gastrointestinal surgery

• American Society of Anesthesiologists class II to III

• Aged between 65 and 80 years old

• Weight between 45 and 75 kilogram,Body Mass Index between 19 and 24 kg.m-2

• With primary hypertension reaching or more than 1 year

• Normal cognitive function,mini-mental state examination more than 27

Exclusion Criteria:

• Severe arrhythmia,atrioventricular block and secondary hypertension

• Liver and kidney dysfunction,pulmonary disease,endocrine disease

• Suspected or confirmed difficult airway

• Any disease or pathologic change will interfere study result

• Inability to exchange with serious visual and hearing impairment

• Long term use of sedative-hypnotic drugs and antidepressant drug

• Addicted to alcohol, tobacco or drug

• Neuromuscular disease

• Suspected of malignant hyperthermia

• Allergic to investigational products or with other contraindication

• Participated in other study within 30 days