Effects of Dexmedetomidine vs Midazolam on Microcirculation in Septic Shock Patients

• Status: Unknown status
• Trial end date: 2018-12-31
• Target enrollment: 0
• Participant gender: All

Summary

To investigate changes in the concentration of glucose, lactate, pyruvate and glycerol in the extracellular fluid of the skeletal muscle following Dexmedetomidine administration in patients with septic shock.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Military Hospital of Tunis
• Treatments: Dexmedetomidine; Glycerol; Midazolam; Remifentanil

Criteria

Inclusion Criteria:

• Patients aged over 18 years

• Septic shock requiring norepinephrine (NE) to maintain a mean arterial pressure (MAP) of at least 65mm Hg despite appropriate volume resuscitation (fluid challenge of 20 mL/kg-40 mL/kg)

• Septic shock criteria were defined according to the new Sepsis-3 definition

Exclusion Criteria:

• pregnancy

• uncontrolled hemorrhage

• terminal heart failure

• significant valvular heart disease

• documented or suspected acute coronary syndrome, and limitations on the use of inotropes: left ventricle outflow obstruction, systolic anterior motion of the mitral valve

• refractory bradycardia (heart rate slower than 60 bpm despite of adequate treatment)

• 2nd and 3rd degree of AV-block ,the onset of septic shock more than 24 h before enrollment ,

• APACHE II > 30 at enrollment

• Severe liver cirrhosis (Child B or C)

• New onset of myocardial infarction within 30 days or heart failure (NYHA 4)

• attending other trial in ICU within one month

• allergic history to dexmedetomidine