Effects of Dexmedetomidine on Postoperative Cognitive Dysfunction During One-lung Ventilation in Elder Patients

• Status: Unknown status
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is to explore the effects of dexmedetomidine on postoperative cognitive dysfunction during one-lung ventilation in elder patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Tang-Du Hospital
• Treatments: Anesthetics; Dexmedetomidine; Etomidate; Midazolam; Propofol; Remifentanil; Rocuronium; Sufentanil; Vecuronium Bromide

Criteria

Inclusion Criteria:

• Written informed consent.

• Ongoing one-lung ventilation surgery.

• American Society of Anesthesiologists class I to III.

• Aged between 55 and 75 years old.

• Body Mass Index between 18 and 25 kg/m2.

Exclusion Criteria:

• Systolic blood pressure more than 180 mmHg or lower than 90 mmHg,diastolic blood pressure more than 110 mmHg or lower than 60 mmHg.

• Serious heart,liver,kidney, pulmonary, and endocrine disease or serious infection.

• Suspected or confirmed difficult airway.

• History of abnormal anesthesia.

• Suspected of malignant hyperthermia.

• Use of sedative and antidepressant drug or serious alcoholism

• Mini-mental State Examination less than 17.

• Highest academic degree below grade 6 in primary schools

• Patients inability to exchange with serious visual and hearing impairment or mental disability.

• History of shock.

• Carotid artery stenosis and central nervous system disease such as stroke, epilepsy.

• Allergic to investigational products or with other contraindication.

• Participated in other study within 30 days .