Effects of Dexmedetomidine on Cardiac Electrophysiology in Patients Under General Anesthesia During Perioperative Period
Status:
Completed
Trial end date:
2021-03-16
Target enrollment:
Participant gender:
Summary
Perioperative stress may increase the incidence of adverse events in the cardiovascular
system and lead to poor prognosis. Dexmedetomidine is a highly selective α2 adrenergic
receptor agonist, which can inhibit stress response and reduce hemodynamic fluctuations. In
different usage plans, dexmedetomidine can have different effects on hemodynamics, myocardial
electrical activity, cardiac function. The main purpose was to observe its effects on
myocardial electrophysiology and cardiac function during perioperative period. The secondary
purpose was to explore the optimal dose of dexmedetomidine that has the least adverse effects
on perioperative electrocardia action and cardiac function