Effects of Dexmedetomidine and Dopamine on Renal Function After Major Surgery
Status:
Unknown status
Trial end date:
2019-12-01
Target enrollment:
Participant gender:
Summary
Acute kidney injury (AKI) is associated with complications that may lead to multiorgan
dysfunction and potentially to multi-organ failure after major surgery. Dexmedetomidine is a
highly selective alpha(2)-adreno receptor agonist widely used during anesthesia. In animals,
dexmedetomidine has shown protective effects in AKI after surgery. Dopamine (DA) is an
organic chemical of the catecholamine and phenethylamine families that has been widely used
to increased renal blood flow and urine output during surgery. However, the clinical effects
of dexmedetomidine and dopamine on renal function are still controversial. The aim of this
study is to investigate whether dexmedetomidine and dopamine have positive effects on renal
function after selective major surgery.