Effects of Dexmedetomidine Sedation on Delirium and Haemodynamic in Mechanical Ventilated Elderly Patients

• Status: Unknown status
• Trial end date: 2015-07-01
• Target enrollment: 0
• Participant gender: All

Summary

This study was designed to observe the effects of dexmedetomidine on delirium and haemodynamic in mechanical ventilated elderly patients,and to evaluate the safety of dexmedetomidine.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fuling Central Hospital of Chongqing City
• Treatments: Dexmedetomidine; Fentanyl; Midazolam

Criteria

Inclusion Criteria:

• Written informed consent

• Intensive care unit patients who need mechanical ventilation

• Anticipate duration of mechanical ventilation longer than 24 hours,and shorter than 96 hours prior to giving investigational products

• Acute physiology and chronic health evaluation II score more than 10

• Aged between 60 to 80 years old

• Weight between plus or minus 20% of the standard weight. Male: (height cm - 80) × 70% = standard weight Female: (height cm - 70) × 60% = standard weight

Exclusion Criteria:

• Trauma and burn patients

• Any kind of dialysis

• Suspected or confirmed difficult airway

• Use of neuromuscular blocking drugs(Except using for intubation )

• Neuromuscular disease

• Epidural or subarachnoid anesthesia

• Plan to give general anesthesia before 24 hours drugs intervention or after giving investigational drugs

• Serious central nervous system disease

• Mental disability or mental disease

• Acute hepatitis and serious liver disease(Child-Pugh C)

• Unstable angina and acute myocardium infarction

• Left ventricular ejection volume less than 30%,heart rate less than 50 beats per minute

• II and III degree atrioventricular block

• Systolic pressure less than 90 mmHg after giving vasopressors twice before beginning of this study

• Consciousness disturbance patients whose blood pressure less than 70mmHg and blood lactate more than 4.0mmol/L

• Suspected or confirmed long term use of narcotic analgesics

• Subjects who are breastfeeding or pregnant

• Allergic to investigational products or with other contraindication

• Participated in other study within 30 days