Effects of Denosumab on Bone Microarchitecture After Total Knee Arthroplasty
Status:
Not yet recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
This study evaluates single dose of Denosumab in decreasing systemic and periprosthetic bone
resorption after Total Knee Arthroplasty compared to placebo in 60 patients (30 placebo and
30 Denosumab) within 2 months after surgery. This study also evaluates the anti-RANKL effect
of single dose of Denosumab in serum, skeletal muscle, synovium, fat, and cartilage.