In this study, the investigators would like to analyze the bone mineral density (BMD) , bone
turnover makers, and fracture prevention effects of denosumab in Japanese patients under
clinical practice. The participants are treated in the investigators hospital, who are under
severe osteoporotic condition.
The main objective of this study is to investigate effects of denosumab. The researchers also
investigate the effects of Effects of previous osteoporotic therapy to denosumab treatment.
In this study, the investigators analyse the determinants of subsequent BMD increase and
fracture preventing effect by teriparatide.