Effects of Dapagliflozin and Metformin on Vascular Function in Newly-Diagnosed Treatment-Naive Type 2 Diabetes

• Status: Recruiting
• Trial end date: 2023-05-10
• Target enrollment: 0
• Participant gender: All

Summary

Trial Design: This is a 12 week randomised controlled open label trial comparing the impact of Dapagliflozin, Metformin and combination therapy on vascular function in newly diagnosed T2DM patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Tan Tock Seng Hospital
• Treatments: Dapagliflozin; Metformin

Criteria

Inclusion Criteria:

1. Ability to give informed consent

2. Age 30-65 years

3. Newly diagnosed (within the past 1 - 2 years) to have T2DM and not started on diabetes medications, HbA1c 6.4% to 10% (both inclusive) and/or OGTT 0 min glucose ≥7.0mmol/L and/or 120 min glucose ≥11.8mmol/L OR Recently diagnosed to have T2DM and treated with Metformin for not more than 5 years, HbA1c ≤ 8%

4. No recent change in medications or new medications

5. eGFR>60mL/min/1.73m2

6. Patient is otherwise well with no acute systemic illness in the last 2 weeks.

7. Female participants of child bearing potential and male participants whose partner is of child bearing potential must be willing to ensure that they or their partner use effective contraception during the trial

Exclusion Criteria:

1. History of ketoacidosis or any other conditions causing acidosis e.g. Alcohol dependence

2. Has a history of urinary tract infections or is at risk for urinary tract infections (e.g prostatomegaly, vesicoureteric reflux, kidney stones)

3. Patients on corticosteroids or immunosuppressive agents

4. Patients known to have HIV infection and/or on anti-retroviral agents

5. Patients with typical clinical features suggestive of T1DM (young onset with no family history of diabetes or first presentation as DKA were excluded). The endocrinologist (PI or co-I) will look at the patient profile to confirm diagnosis of T2DM.

6. Has severe liver dysfunction

7. Considered inappropriate by investigators due to any other reason.

8. Female participant who is pregnant, lactating or planning pregnancy during the course of the trial.

9. Significant renal impairment.

10. Scheduled elective surgery or other procedures requiring general anaesthesia during the trial.

11. Participants who have participated in another research trial involving an investigational product in the past 12 weeks.

12. Participants who have a history of Peripheral Arterial Disease or peripheral vascular disease or complains of lower limb claudication pain.

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