Overview

Effects of Clomiphene Citrate Ovulation Induction on Frozen Embryo Transfer

Status:
Unknown status
Trial end date:
2018-06-30
Target enrollment:
0
Participant gender:
Female
Summary
Clomiphene citrate has been widely used for treatment of infertility for decades. Although its anti-estrogenic effects leads to low pregnancy rate, clomiphene citrate is still a first-line treatment for ovulation induction because of its simple usage, low prices, no injection and low risk of ovarian hyperstimulation syndrome. Clomiphene citrate shows high affinity with estrogen receptor, which inhibits endometrial proliferation, inevitably leads to a decline in endometrial receptivity, thus affecting the success rate of IVF. In that case, use clomiphene citrate for ovulation induction is lost more than gained based on fresh embryo transfer. But recently, some researchers have proposed to extend the time from ovulation induction to embryo transfer, and the increased level of estradiol can replace clomiphene citrate to combine with the receptor, so that the uterine environment is more conducive to pregnancy. Therefore, use clomiphene citrate based on vitrification of embryo maybe a good way for treatment of infertility. At present, using frozen embryo transplantation after ovulation induction by clomiphene citrate is a common treatment, but few research has mentioned the best time for embryo implantation. The investigators research is to find the most appropriate time for frozen embryo implantation after using clomiphene citrate for ovulation induction.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
ShangHai Ji Ai Genetics & IVF Institute
Treatments:
Citric Acid
Clomiphene
Enclomiphene
Zuclomiphene
Criteria
Inclusion Criteria:

Women 18-40 years of age who are scheduled for IVF or ICSI in our IVF institute while
meeting the following criteria:

1. AMH ≥ 2;

2. Infertility factors: tubal factor, severe oligospermia, etc;

3. FET cycle;

4. Cleavage stage embryo transfer (Day 3).

Exclusion Criteria:

1. BMI ≤ 18.4 or ≥ 25.0;

2. Have pregnancy complications;

3. Genital tract malformations, uterine cavity diseases, PCOS;

4. Endometriosis;

5. Genetic diseases, severe somatic diseases, mental disorder.