Effects of Clomiphene Citrate Ovulation Induction on Frozen Embryo Transfer
Status:
Unknown status
Trial end date:
2018-06-30
Target enrollment:
Participant gender:
Summary
Clomiphene citrate has been widely used for treatment of infertility for decades. Although
its anti-estrogenic effects leads to low pregnancy rate, clomiphene citrate is still a
first-line treatment for ovulation induction because of its simple usage, low prices, no
injection and low risk of ovarian hyperstimulation syndrome. Clomiphene citrate shows high
affinity with estrogen receptor, which inhibits endometrial proliferation, inevitably leads
to a decline in endometrial receptivity, thus affecting the success rate of IVF.
In that case, use clomiphene citrate for ovulation induction is lost more than gained based
on fresh embryo transfer. But recently, some researchers have proposed to extend the time
from ovulation induction to embryo transfer, and the increased level of estradiol can replace
clomiphene citrate to combine with the receptor, so that the uterine environment is more
conducive to pregnancy. Therefore, use clomiphene citrate based on vitrification of embryo
maybe a good way for treatment of infertility.
At present, using frozen embryo transplantation after ovulation induction by clomiphene
citrate is a common treatment, but few research has mentioned the best time for embryo
implantation. The investigators research is to find the most appropriate time for frozen
embryo implantation after using clomiphene citrate for ovulation induction.