Effects of Cannabis Administration Routes on Human Performance and Pharmacokinetics
Status:
Completed
Trial end date:
2016-04-27
Target enrollment:
Participant gender:
Summary
Background:
- Marijuana (cannabis) is an illegal drug. Researchers want to study people s reactions,
attention, and behavior after they take marijuana in different ways. They want to learn
better ways to detect drugs in a person s body They also want to know how long marijuana can
be found in blood, urine, saliva, and breath.
Objectives:
- To learn how people respond to delta-9-tetrahydrocannabinol (THC, a marijuana component)
and how their bodies handle it after it is given in different ways.
Eligibility:
- Adults age 18 50 who use marijuana.
Design:
- Participants are screened under another NIDA protocol.
- This study involves up to 6 visits to NIDA.
- At the first visit, participants will practice the tasks and tests they will do at their
dosing sessions. They will learn how to give breath and saliva samples.
- Dosing sessions 1 4 will last 3 5 days each. All participants will be admitted to a
research clinic the night before these sessions. Some participants can stay at the
clinic and some must go home between sessions.
- At each session, participants will eat a brownie with placebo or marijuana. Then they
will smoke a placebo or marijuana cigarette. Some will inhale placebo or marijuana after
it is vaporized.
- Throughout the sessions:
- Participants will give urine, saliva, and breath samples. Their blood will be taken with
a tube in a vein and finger pricks. Their vital signs will be checked.
- Participants will answer questionnaires and take thinking tests. They will also take
tests that assess eye movement, balance, and time estimation.
- Participants may have a 5th dosing session. They will eat a marijuana brownie and have
the above tests and samples.