Effects of Bupivacaine and Levobupivacaine on Cerebral Oxygenation During Intrathecal Anesthesia in Elderly Patients
Status:
Completed
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
Elderly patients with hip fracture are frail due to associated comorbidity. In these
situations, regional anesthesia is recommended as it is associated to less postoperative
cognitive dysfunction. However, hypotension during the process may impair ischemic
cardiopathy and induce a cerebrovascular stroke. Selection of the right anesthetic agent and
the administration of vasoactive drugs during the process can minimize these risks. Although
bupivacaine and levobupivacaine share pharmacokinetic and pharmacodynamic properties, the
studies show conflicting results. The aim of this study is to investigate if there are
clinically relevant differences between these two drugs in terms of hemodynamic parameters
during the surgical process with special focus on the effects on regional cerebral oximetry
and cognitive status after surgery.