Effects of Broccoli Sprout Extract on Allergy Rhinitis

• Status: Completed
• Trial end date: 2019-03-12
• Target enrollment: 0
• Participant gender: All

Summary

Allergic rhinitis is a common illness suffered among US Veterans. There are medications that help relieve allergy symptoms, including nasal steroid sprays and antihistamines. Some patients have increase symptoms with exposure to their trigger, such as a grasses when combined with pollution due to oxidative stress from pollution. In this study, patients with allergic rhinitis to grass will be given broccoli sprout extract that contains an antioxidant sulforaphane do see if there is beneficial effect in these patients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: VA Office of Research and Development
• Treatments: Antioxidants; Fluticasone

Criteria

Inclusion Criteria:

Inclusion Criteria

1. Females and males 18 years or older.

2. History consistent with seasonal allergic rhinitis consistent with grass allergy (symptoms during summer months, June through August, for at least two consecutive seasons).

3. Not currently taking any medications for allergic rhinitis.

4. Provide written informed consent.

5. Willing and able to comply with all aspects of the protocol.

Exclusion Criteria:

1. The subject has any uncontrolled or serious disease, or any medical or surgical or condition that in the opinion of the investigator(s) could affect the subject's safety and/or interfere with the study assessments.

2. History of anaphylaxis to environmental allergens or an unknown trigger.

3. History of broccoli allergy

4. Recent upper respiratory infection (less than 4 weeks prior to study) or other active Infection.

5. Active smoker

6. Currently receiving allergy immunotherapy.

7. History of rhinitis exacerbation within the past 2 weeks.

8. Use of non-selective Beta-Blocker.

9. Inability to give written informed consent.

10. History or evidence of non-stable cognitive capacity within less than 1 year (i.e. Alzheimer's disease, dementia, bipolar disorder) that in the opinion of the investigator(s) could affect the subject's safety and/or interfere with the study assessments.

11. Pregnancy

12. Perennial rhinitis

13. Uncontrolled asthma

14. Forced Expiratory Volume in 1 second <70% predicted at screening.