Effects of Brain Beta-Amyloid on Postoperative Cognition
Status:
Recruiting
Trial end date:
2022-06-01
Target enrollment:
Participant gender:
Summary
Postoperative cognitive decline (POCD) affects up to 50% of non-cardiac surgical patients
greater than or equal to 65 years of age.
This study will test the hypothesis that preoperative presence of brain beta-amyloid plaques
in non-demented subjects increases postoperative cognitive decline (POCD) in elderly subjects
scheduled for hip or knee replacement.
The investigators hypothesize that preoperative beta-amyloid plaques will predict
postoperative cognitive decline.
Phase:
Phase 4
Details
Lead Sponsor:
University of California, San Francisco
Collaborators:
Alzheimer's Drug Discovery Foundation Alzheimer’s Drug Discovery Foundation Avid Radiopharmaceuticals