Effects of Bosentan (Tracleer) in the Course of Pulmonary Artery Hypertension Induced by Hypoxia
Status:
Completed
Trial end date:
2008-04-01
Target enrollment:
Participant gender:
Summary
Excessive rise in pulmonary artery pressure induced by low oxygen tension (hypoxia) is one of
the factors implicated in high-altitude pulmonary oedema. Plasma ET1 increases in subjects
exposed to high altitude and is correlated to pulmonary artery pressure.
The aim of the study is to investigate whether blockade of ET1 receptors would reduce the
acute rise in systolic pulmonary artery pressure induced by hypoxia.