Effects of Bolus Surfactant Therapy on Peripheral Perfusion Index and Tissue Carbon Monoxide

• Status: Completed
• Trial end date: 2013-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Exogenous bolus surfactant administration may affect hemodynamic parameters and peripheral perfusion. Surfactant therapy is commonly used for respiratory distress syndrome in premature infants, which is also associated with inflammation. There are different types and doses of surfactant preparations available. With the help of new generation monitors, changes in peripheral perfusion and transcutaneous CO, a marker of inflammation, may be demonstrated.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ege University
• Treatments: Beractant; Carbon Monoxide; Pulmonary Surfactants

Criteria

Inclusion Criteria:

• Gestational age between 26 and 36 weeks

• intubated for respiratory distress syndrome

Exclusion Criteria:

• cardiac defects,

• hemodynamically significant patent ductusarteriosus,

• congenital pneumonia,

• early sepsis

• unstable infants in need of inotropic support.