Effects of Bisphosphonates and Nutritional Supplementation After a Hip Fracture

• Status: Completed
• Trial end date: 2009-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The study hypothesis is that nutritional supplementation together with bisphosphonates have a better preserving effect on bone mineral density (BMD) after hip fracture than bisphosphonates alone and that nutritional supplementation given postoperatively for 6 months preserve lean body mass in elderly hip fracture patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Karolinska Institutet
• Treatments: Calcium; Calcium, Dietary; Cholecalciferol; Diphosphonates; Ergocalciferols; Etidronic Acid; Risedronate Sodium; Risedronic Acid; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Age ≥ 60 years

• Recent fracture of the femoral neck or trochanter

• Without severe cognitive impairment

• Ambulant before fracture

• BMI ≤ 28

Exclusion Criteria:

• Abnormal parameters regarding liver i.e. S-Alanine aminotransferase (S-ALAT) and S-Aspartate aminotransferase (S-ASAT) ≥ twice as normal

• Abnormal parameters regarding kidney i.e. S-Creatinine > 130 µg/L

• Primary hyperparathyroidism, osteogenesis imperfecta, Paget´s disease

• Myeloma

• Lactose intolerance

• Dysphagia

• Esophagitis

• Gastric ulcer

• Malignancy

• Diabetes with nephropathy or retinopathy

• Active iritis or uveitis