Effects of Atazanavir Treatment on Type 2 Diabetes Mellitus Related Endothelial Dysfunction

• Status: Completed
• Trial end date: 2009-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether atazanavir use is of influence on the endothelial dysfunction associated with type 2 diabetes mellitus.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Radboud University
• Collaborator: Dutch Diabetes Research Foundation
• Treatments: Atazanavir Sulfate

Criteria

Inclusion Criteria (most important):

• 18 - 70 years

• type 2 diabetes mellitus treated with diet, oral medication and/or insulin

• BMI of 18 to 35

• determinants of renal and hepatic function within twice the upper limit of normal range, abnormalities in lipid profile permitted

Exclusion Criteria (most important):

• history of smoking within past year

• history of or current abuse of drugs, alcohol or solvents

• current use of antihypertensive, cardiac or other vasoactive medication

• clinical evidence of cardiac or pulmonary disease