Effects of Apelin on the Lung Circulation in Pulmonary Hypertension

• Status: Unknown status
• Trial end date: 2014-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the effects of Apelin on the lung circulation. The investigators hypothesise that Apelin will relax the lung blood vessels and improve the pumping ability of the heart.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Golden Jubilee National Hospital
• Collaborators: Imperial College Healthcare NHS Trust; NHS Lothian

Criteria

PULMONARY ARTERIAL HYPERTENSION

Inclusion Criteria:

• Pulmonary Arterial Hypertension which is Idiopathic, Heritable, associated with connective tissue disease or associated with drugs/toxins

• mean pulmonary artery pressure >/= 25mmHg

• pulmonary capillary wedge pressure < 15 mmHg

• normal/reduced cardiac output

• stable

• WHO functional class II - IV

Exclusion Criteria:

• significant left ventricular dysfunction

• chronic lung disease (FEV1 < 60% or abnormal CT)

• chronic thromboembolic pulmonary hypertension

HEART FAILURE

Inclusion Criteria:

• stable on treatment for 3 months prior to study

• NYHA grade II - IV

• ejection fraction <35%, left ventricular end-diastolic diameter > 5.5 cm and/or shortening fraction < 20%

• Tricuspid regurgitant velocity >/= 3.0 m/s

HEALTHY VOLUNTEERS

Inclusion Criteria:

• mean pulmonary artery pressure < 25 mmHg

• tricuspid regurgitant velocity < 2.5 m/s

Exclusion Criteria:

• obstructive coronary artery disease

ALL SUBJECTS

Exclusion Criteria:

• bleeding diathesis

• women of childbearing potential without pregnancy test

• systolic blood pressure > 190 mmHg or < 100 mmHg

• malignant arrhythmias

• renal or hepatic failure

• haemodynamically significant valvular heart disease

• severe or significant co-morbidity

• pacemaker

• already taking part in another trial

• lack of informed consent