Effects of Antioxidant Dentifrice on Gingivitis

• Status: Completed
• Trial end date: 2007-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate the effect of a dentifrice containing L-ascorbic acid 2-phosphate magnesium salt on gingival inflammation, gingival bleeding and gingival redness.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Lion Corporation
• Collaborators: Nihon University; Osaka University; Tohoku University
• Treatments: Antioxidants; Ascorbate-2-phosphate; Ascorbic Acid; Fluorides

Criteria

Inclusion Criteria:

• Age between ≥ 20 and < 65 y with at least 16 permanent teeth.

• Gingival inflammation or mean baseline GI ≥ 0.5 without severe periodontal disease enough to require professional therapy.

• Written informed consent to participate.

Exclusion Criteria:

• Taking medications that could influence periodontal tissue health, such as antimicrobials and antihypertensives within 1 month before starting the trial.

• Use of orthodontic appliances.

• Pregnancy or planning to become pregnant during the trial period.

• Previous participation in any other clinical trial.

• Inability of patient to understand the study purpose and/or study protocols.

• Judged unsuitable by investigators for other reasons.