Effects of Antihypertensive Drugs in Patients With Hypertension and Obstructive Sleep Apnea (OSA)

• Status: Completed
• Trial end date: 2013-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the present study is to compare the effects of different types of antihypertensive drugs (angiotensin II receptor blockers and long-acting calcium channel blockers) in patients with hypertension and obstructive sleep apnea who are not controlled well with their hypertension after continuous positive airway pressure therapy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kyoto University, Graduate School of Medicine
• Treatments: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Antihypertensive Agents; Calcium Channel Blockers; Calcium, Dietary; Olmesartan; Olmesartan Medoxomil

Criteria

Inclusion Criteria:

• Apnea and hypopnea index of more than 20 /hr, and treated with CPAP

• Uncontrolled hypertension (defined as systolic blood pressure of more than 130 mmHg or diastolic blood pressure of more than 80 mmHg

Exclusion Criteria:

• Cerebrovascular diseases, myocardial infarction, angina pectoris or heart failure within 6 months

• Uncontrolled arrhythmia

• Severe hepatic or renal disorders

• Having poor prognosis disorders such as malignant disorders