Effects of Angiotensin II Receptor Blocker Compared With Diuretics in High-risk Hypertensive Patients
Status:
Unknown status
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
The aim of the study is to investigate the optimized treatment strategy of hypertension, so
as to make more patients to reach the blood pressure goals and to reduce
cardio-cerebrovascular events. Objective and Methods: Patients are eligible for inclusion in
the study if they are essential hypertension, 50-79 years of age with at least one
cardiovascular risk factor and sign the informed consent forms. This project is a
multi-centre, prospective randomized,，openlabel blind-endpoint evaluation controlled (PROBE)
trial. 12000 patients will be randomly assigned to either of low-dose Amlodipine+Telmisartan
group or Amlodipine+ diuretics group. Among those patients with serum cholesterol between
4.0-6.1mmol/L, they will be also randomized into small dose of statin-based regimen or
standard management regimen; Patients will also randomly assigned to intensive lifestyle
intervention group or standard intervention group according to the community area where the
patients in.
Phase:
Phase 4
Details
Lead Sponsor:
Chinese Academy of Medical Sciences, Fuwai Hospital