Effects of Androgen Blockade on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone
Status:
Terminated
Trial end date:
2017-08-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to understand the effects of elevated male hormones in
adolescent girls and how they effect the development of polycystic ovary syndrome (PCOS). If
the investigators understand the effects of elevated male hormones levels in girls, the
investigators may be able to better treat girls with elevated male hormone levels and perhaps
even learn how to prevent the development of PCOS. Females with elevated levels of male
hormones respond differently to estrace (estradiol) and progesterone than females with normal
male hormone levels. The investigators will be giving you estrogen and progesterone to see
how you respond after the male hormone has been blocked by a medication called flutamide.
Phase:
N/A
Details
Lead Sponsor:
University of Virginia
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)