Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase with allopurinol might affect diastolic function in patients with CHF.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universita di Verona
• Treatments: Allopurinol

Criteria

Inclusion Criteria:

• chronic heart failure;

• left ventricular systolic dysfunction (ejection fraction <45%)

• stable clinical conditions in the previous three months

• optimal medical therapy for CHF

• normal sinus rhythm

• written informed consent

• age >18 years

Exclusion Criteria:

• renal failure (s-creatinine >2.5 mg/dl)

• already on allopurinol

• malignancies

• chronic inflammatory diseases