Effects of Alkaline Phosphatase on Renal Function in Septic Patients
Status:
Completed
Trial end date:
2006-03-01
Target enrollment:
Participant gender:
Summary
Septic shock is the most common cause of death in patients requiring intensive care. The
kidney is one of the first organs to fail, stressing the importance to search for clinical
interventions that may protect the kidneys during sepsis.
Alkaline phosphatase functions as a host defence molecule and is present in many cells and
organs (e.g. intestine, placenta, liver, kidney and bone). Alkaline phosphatase has a dual
mode of action. First, it binds to and, subsequently, dephosphorylates lipopolysaccharide
(LPS). Second, the enzymatic reaction product monophosphoryl-LPS is a non-toxic substance for
mammals which acts as a partial antagonist on the LPS receptor complex. In several animal
studies, administration of alkaline phosphatase attenuates the inflammatory response and
reduces mortality.
It is unknown whether these results can be extrapolated to septic patients . We studied the
effects of alkaline phosphatse administration on kidney damage and function in patients with
severe sepsis or septic shock.