Effects and Safety of Taurine Granule on Blood Pressure in Prehypertensive
Status:
Completed
Trial end date:
2015-03-01
Target enrollment:
Participant gender:
Summary
Prehypertension are associated with an increased risk of atherosclerosis and coronary artery
disease, and often complicated with the metabolic disorder of glucose and lipid. The
comprehensive prevention of hypertension is still an important and complex clinical issue.
Taurine is one of the ingredients of Chinese medicine bezoar ,as an endogenous amino acids is
central inhibitory neurotransmitter, can regulate the excitability of nerve tissue, regulate
body temperature, therefore, antipyretic, sedative, analgesic, anti-inflammatory,the role of
anti-rheumatic, anti-convulsant. In addition, Taurine inhibits platelet aggregation in the
circulatory system, lower blood lipids, to maintain the body's normal blood pressure and
prevent atherosclerosis; protective effect on myocardial cells, can be anti-arrhythmic;
special efficacy to lower blood cholesterol, to treat heart failure. The effect of oral
Taurine on blood pressure is not consistent, however, many animal study has shown that oral
administration of Taurine, could reduce 24-hour mean arterial systolic and diastolic blood
pressure in spontaneous hypertensive rats. Furthermore, Taurine interfere with calcium and
low affinity binding of the calcium binding sites, decrease the voltage-dependent Ca2+channel
in vascular smooth muscle relaxation, vasodilation, lower blood pressure.In a prospective,
double-blind, randomized, and parallel-group study, we will evaluate the effects of Taurine
granule on blood pressure and metabolic parameters in prehypertensive and mild hypertensive
patients. This study will help develop future comprehensive prevention and treatment
strategies for hypertension.