Effects Of Losartan On Myocardial Structure In Diabetic Hypertensive Patients With Left Ventricular
Status:
Unknown status
Trial end date:
2009-04-01
Target enrollment:
Participant gender:
Summary
The anthypertensive treatment with Losartan may have benefits beyond blood pressure reduction
on myocardial structure and function in hypertensive diabetic patients. We will evaluate the
effect of losartan treatment on structural characteristics of myocardium in hypertensive
diabetic patients:
1. left ventricular mass, intraventricular septal thickness, fractional shortening.
2. myocardial qualitative alteration and heterogeneity of myocardial tissue that describes
myocardial texture and echodensity, related to collagen deposition; myocardial
qualitative alteration will be evaluate by ultrasonic myocardial integrated backscatter
signals (IBS) both as peak end diastolic signal intensity and as cardiac cyclic
variation
3. alteration of diastolic function as studied by Doppler flow velocities across the mitral
valve (Pulse Wave Doppler) and pulse wave Tissue Doppler Imaging parameters
4. aortic strain and distensibility (that is in relation with LVH)
5. epicardial adipose tissue measurement (this parameter is related to the visceral fat and
may be an easy method to indicate patients with high cardiovascular risk).