Effectiveness on Smooth Extubation According to the Administration Time of Sugammadex
Status:
Not yet recruiting
Trial end date:
2024-04-03
Target enrollment:
Participant gender:
Summary
After surgery is completed under general anesthesia, extubation is performed after recovery
from anesthesia, and during this process, bucking, coughing, and rapid and excessive
hemodynamic fluctuations occur very often. These phenomena can lead to high intrathoracic
pressure, venous congestion, hematoma formation, or increased bleeding after major neck
surgery. (1) They can also increase the risk of aerosol generation, which can transmit
infection to health care workers. (2) For this, smooth extubation is required. Methods of
administering drugs such as lidocaine, opioids, or dexmedetomidine have been proposed for
smooth extubation. (3-5) As a disadvantage, the use of these drugs may be associated with
deep sedation and reduced airway reflexes .
Recently, Babu et al. (6) reported that bucking and coughing during extubation could be
reduced by changing the timing of administering a muscle relaxant antagonist rather than
using these sedative drugs, and thus complications related to extubation could be reduced. In
general, in the awakening process, it was common to administer the muscle relaxant at the
point of recovery of spontaneous breathing. However, Babu et al. demonstrated the possibility
of safe and smooth extubation by changing the timing of administering neostigmine without the
use of sedatives or narcotic analgesics, but there are few studies on sugammadex.
Therefore, when recovering from general anesthesia, sugammadex was administered before and
immediately after extubation to evaluate and compare smooth extubation (ie, comparison of the
frequency of bucking and coughing).