Effectiveness of the Use of Methyldopa in Comparison to Captopril in Hypertension Post Partum
Status:
Enrolling by invitation
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
In hypertensive mothers, it is common in clinical practice to substitute methyldopa for
another medication, such as captopril, immediately after delivery, which may, as a
consequence, cause a rebound effect or an initial lack of blood pressure control until the
new medication had a more complete action. Thus, the treatment of hypertension in the
puerperium is generally guided by expert opinion and recommendations for guidelines, based on
non-robust evidence. OBJECTIVE: To evaluate the control of blood pressure in postpartum women
with hypertensive syndromes during pregnancy with the maintenance of the continued use of
previously used methyldopa compared to switching from antihypertensive regimen to the use of
captopril. METHOD: Randomized, double-blind, drug controlled clinical trial. EXPECTED RESULT:
better pressure control with the continued use of methyldopa.