Effectiveness of iPRF Injections in Temporomandibular Joints Degeneration Management
Status:
Not yet recruiting
Trial end date:
2025-12-31
Target enrollment:
Participant gender:
Summary
The aim of the study is to evaluate the effectiveness of intra-articular platelet-rich fibrin
(iPRF) injections in the management of moderate and mild cases of degeneration of the
temporomandibular joints. This randomized, two-arm controlled trial will involve 40 adult
patients diagnosed with mild or moderate degeneration of the temporomandibular joints on the
basis of clinical examination and magnetic resonance imaging or computed tomography.
Qualified study participants will be randomly assigned to two groups. The studied group will
receive two injections of iPRF with an interval of 30 days, while the control group will
receive injections of 10% dextrose during this time. Each subject will be tested on the day
of the first injection (D0), on the day of the second injection (D30), and then 60 (D60) and
12 (D120) days after the first injection using MRI/CT, Doppler Hi-dop, clinical examination
and surveys.